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Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Chemical and Pharmaceutical Bulletin (2008) 56(10) 1490-1495
DOI: 10.1248/cpb.56.1490
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Abstract

Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM. © 2008 Pharmaceutical Society of Japan.

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Misawa, T., Aoyama, H., Furuyama, T., Dodo, K., Sagawa, M., Miyachi, H., … Hashimoto, Y. (2008). Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. Chemical and Pharmaceutical Bulletin, 56(10), 1490–1495. https://doi.org/10.1248/cpb.56.1490

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