Molecular diversity of four-component synthesis of pyrazole-based pyrido[2,3-d]pyrimidine-diones in water: A green synthesis

Abstract

A novel one pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-diones, involving, hydrazine hydrate, ethyl acetoacetate, 6-amino-1,3-dimethyl uracil and an appropriate aryl aldehyde in the presence of two green catalysts in water, is reported.