A case report of McCune –Albright syndrome with hepatic manifestations

Abstract

McCune–Albright syndrome is a non‐hereditary disease characterized by café‐au‐lait skin spots, fibrous dysplasia of bone, and endocrinopathies. We report a boy with a history of repeated hospitalizations from birth due to severe jaundice and hyperthyroidism. At the age of 2 years, he suffered from a proximal left femoral fracture. During the follow‐up, liver function tests were abnormal. Considering the clinical and paraclinical findings, the patient was diagnosed with McCune–Albright syndrome. In McCune–Albright syndrome, functional mutations in the GNAS can cause a wide range of clinical phenotypes. Considering the previously reported cases and the mentioned case, neonatal jaundice can be an early sign of this syndrome.