Peripheral giant cell granuloma

Abstract

The peripheral giant cell granuloma (PGCG), also known as osteoclastoma, giant cell reparative granuloma, giant cell epulis or giant cell hyperplasia, is a relatively frequent reactive benign exophytic lesion of the oral cavity originating from the periosteum or periodontal membrane following local irritation or chronic trauma. PGCG manifests as a red-purple nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells located in the region of the gums or edentulous alveolar margins, fundamentally in the lower jaw. The lesion can develop at any age, though it is more common between the fifth and sixth decades of life, and shows a slight female predilection. PGCG is a soft tissue lesion that very rarely affects the underlying bone, though the latter may suffer superficial erosion. Here, we present a case of PGCG who presented with the chief complaint of nasal blockade with a palatal mass. © Jaypee Brothers Medical Publishers (P) Ltd.