MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations

Abstract

Brain arteriovenous malformations (BAVM) have high matrix metalloproteinase-9 (MMP-9) expression, the source of which is unclear. We hypothesized MMP-9 production might be due to inflammation in BAVM. Compared to control brain tissues (n=5), BAVM tissue (n=139) had a higher expression (by ELISA) of myeloperoxidase (MPO) (193±189 vs. 6±3, ng/mg, P