Antiretroviral Agents — How Best to Protect Infants from HIV and Save Their Mothers from AIDS

Abstract

A major question addressed by Jourdain et al. was whether the antiretroviral agents used to prevent mother-to-child transmission of HIV-1 might compromise the efficacy of antiretroviral agents subsequently prescribed for the treatment of HIV-1 infection in the mother. The end point of interest was virologic failure, defined by the failure to achieve maximal suppression (fewer than 50 copies of HIV-1 RNA) six months after the initiation of HAART.