Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa

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Abstract

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6,9 and 8.3/μg/mL respectively.

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Neto, C. C., Vaisberg, A. J., Zhou, B. N., Kingston, D. G. I., & Hammond, G. B. (2000). Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa. Planta Medica, 66(5), 483–484. https://doi.org/10.1055/s-2000-8583

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