MicroRNAs in cell proliferation, cell death, and tumorigenesis

Abstract

MicroRNAs (miRNAs) are a recently discovered class of ∼ 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors. © 2006 Cancer Research UK.