Abstract
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tet-radecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 μg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 μg/mL.
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Júnior, C. O. R., le Hyaric, M., da costa, C. F., Corrêa, T. A., Taveira, A. F., Araújo, D. P., … de Almeida, M. V. (2009). Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Memorias Do Instituto Oswaldo Cruz, 104(5), 703–705. https://doi.org/10.1590/s0074-02762009000500006
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