New Analytical Methods for the Determination of Two Gliptin Drugs In Pharmaceutical Formulations and Urine Samples

Abstract

New ion –associate complexes of the twogliptin drugs, vildagliptin and saxagliptin were precipitated with tetraiodometrcurateand ammonium reineckate and the excess unreacted metal complex was determined. New methods were given for the determination of these drugs in pure solutions, pharmaceutical formulations and urine samples using atomic absorption and atomic emission spectrometry. The drugs can be determined by the afford methods in the ranges 0.68 –74.69 and 0.70 –77.42 μg / mlfor vildagliptin and saxagliptin, respectively.