Effect of internal viral sequences on the utility of retroviral vectors

  • Armentano D
  • Yu S
  • Kantoff P
  • et al.
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Abstract

Expression of the human ADA cDNA encoded by the Moloney murine leukemia virus spliced RNA form is enhanced by intron-contained sequences. The presence of sequences corresponding to the viral gag gene in a Moloney murine leukemia virus-based vector results in the generation of 10- to 40-fold higher titers of virus.

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Armentano, D., Yu, S. F., Kantoff, P. W., von Ruden, T., Anderson, W. F., & Gilboa, E. (1987). Effect of internal viral sequences on the utility of retroviral vectors. Journal of Virology, 61(5), 1647–1650. https://doi.org/10.1128/jvi.61.5.1647-1650.1987

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