Abstract
An aldol condensation is the key to the eight-step linear synthesis of 23-oxa analogues of OSW-1 (e.g. 2) in more than 20% overall yield from the industrially produced steroid 1. Compound 2 is up to 2000 times more potent than cisplatin as an inhibitor of tumor cell growth.
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APA
Shi, B., Wu, H., Yu, B., & Wu, J. (2004). 23-Oxa-analogues of OSW-1: Efficient synthesis and extremely potent antitumor activity. Angewandte Chemie - International Edition, 43(33), 4324–4327. https://doi.org/10.1002/anie.200454237
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