Stereoselective reactions. XXXIII. Design and synthesis of chiral bidentate amines having a bulky group on the chiral carbon

Abstract

Based on the solution structures of chiral bidentate lithium amides ((R)-3a,b) having a phenyl group on the chiral carbon, chiral bidentate amines ((R)-5a,b - 8a,b and (S)-9a,b) having a bulkier group instead of a phenyl group on the chiral carbon were designed and synthesized.