Application of a 5-endo-trig cyclisation in the total synthesis of (+)-preussin

Abstract

The synthesis of 2,5-syn disubstituted pyrrolidines from N-SES protected aziridines is described. The key step in the methodology is a 5-endo-trig cyclisation. Application of this reaction in the synthesis of (+)-preussin is reported. ©ARKAT-USA, Inc.