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Isolation and characterization of cytotoxic diterpenoid isomers from propolis

Zeitschrift fur Naturforschung Section C - Journal of Biosciences (1997) 52(9-10) 702-704
DOI: 10.1515/znc-1997-9-1020
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Abstract

The methanol extract of Brazilian propolis was fractionated by HPLC, based on HUH13 (human hepatocellular carcinoma) cell cytotoxicity assay. Two isomers of diterpenoid with a molecular formula of C20H30O3 (MW: 318.46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, 13E-kolavadien-17-oic acid).

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Matsuno, T., Matsumoto, Y., Saito, M., & Morikawa, J. (1997). Isolation and characterization of cytotoxic diterpenoid isomers from propolis. Zeitschrift Fur Naturforschung Section C - Journal of Biosciences, 52(9–10), 702–704. https://doi.org/10.1515/znc-1997-9-1020

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