Sensory processing by motoneurons: A numerical model for low-level flight control in flies

Abstract

Rhythmic locomotor behaviour in animals requires exact timing of muscle activation within the locomotor cycle. In rapidly oscillating motor systems, conventional control strategies may be affected by neural delays, making these strategies inappropriate for precise timing control. In flies, wing control thus requires sensory processing within the peripheral nervous system, circumventing the central brain. The underlying mechanism, with which flies integrate graded depolarization of visual interneurons and spiking proprioceptive feedback for precise muscle activation, is under debate. Based on physiological parameters, we developed a numerical model of spike initiation in flight muscles of a blowfly. The simulated Hodgkin–Huxley neuron reproduces multiple experimental findings and explains on the cellular level how vision might control wing kinematics. Sensory processing by single motoneurons appears to be sufficient for control of muscle power during flight in flies and potentially other flying insects, reducing computational load on the central brain during body posture reflexes and manoeuvring flight.