O9.5. EMOTIONAL SCENE PROCESSING IN PSYCHOSIS BIOTYPES: FINDINGS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (BSNIP)

Abstract

Background Flat and inappropriate affect and emotional labiality are features of psychosis syndromes and could involve impairments in neural processing of emotional stimuli. Studies have reported abnormal electrophysiological (EEG) responses to emotional stimuli in schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar I disorder with psychosis (BDP). The Bipolar-Schizophrenia Network on Intermediate Phenotypes (BSNIP) has identified three psychosis Biotypes (abbreviated B1, B2 & B3) which display differing patterns of neural activity, but emotional processing has not been assessed in these groups. Methods 814 participants (HC = 197, SZ = 230, SAD = 212, BDP = 175; B1 = 198, B2 = 176, B3 = 243) from the 5-site BSNIP consortium viewed pleasant, neutral, and unpleasant scenes from the IAPS while EEG was recorded from 64 sensors. Using a spatial PCA, two components reduced EEG data to one waveform per component. Spatial components were weighted in the occipital and centroparietal scalp regions and accounted for 56% and 42% of the variance, respectively. Early, mid-latency, and late time bins of interest (80–140 ms, 200–400 ms, & 400–1000 ms) were identified by visual inspection. Data were averaged across bins for each spatial component, yielding 6 spatiotemporal measures. Mixed-design ANOVAs were calculated using DSM and Biotype as between-subjects variables and task as the within-subjects variable. Follow up Tukey tests were conducted as appropriate. Results There were no significant DSM by Biotype interactions for any component/time combination (F = 1.39, 1.40,.92, 1.27, 1.34, 1.08, all p >.05). There was a main effect of DSM for the centroparietal component during the early time bin (F = 5.82, p