THIAZOLE DERIVATIVES AS POTENTIAL ANTIDIABETIC AGENTS

Abstract

Various molecules showing pharmacological activities consist of thiazole as a core structure having heteroatom as sulfur and nitrogen. Thiazole is present in many naturally occurring compounds, along with vitamin B1 and penicillin. Thiazole is used in different biological fields, and it is also known as a wonder nucleus. Thiazole moieties are contained in many new compounds, and hence it is one of the essential areas of research. Diabetes is one of the life-threatening diseases and has become a pandemic presently more than 400 million people are suffering from this and likely to be double by the next ten years. Noncompliance, hypoglycemia, and obesity can be caused by most diabetic drugs. As a result, new antidiabetic drugs with thiazole moieties were synthesized with improved efficacy and minimized side effects. Considering the prominence of the past as well as the latest developments in drugs as an antidiabetic drug having thiazole ring as an antidiabetic drug and its significance, is this described in the present review.