Knockdown of lncRNA MNX1-AS1 suppresses cell proliferation, migration, and invasion in prostate cancer

Abstract

Altered expression of long non-coding RNAs (lncRNAs) has been reported in many malignancies, including prostate cancer. However, the role of lncRNA MNX1-AS1 in prostate cancer has not been reported. Here, we report that MNX1-AS1 is expressed in prostate cancer tissues and cells and that siRNA-mediated knockdown of MNX1-AS1 inhibits proliferation, migration, and invasion of prostate cancer DU145 and PC3 cells. In addition, down-regulation of MNX1-AS1 decreased expression of proliferating cell nuclear antigen, PH-3, N-cadherin, and vimentin, but enhanced expression of E-cadherin. In conclusion, this is the first report that knockdown of MNX1-AS1 suppresses prostate cancer cell proliferation, migration, and invasion. We believe that MNX1-AS1 may be a potential new therapeutic target for prostate cancer patients.