Lichen Simplex Chronicus Itch: An Update

Abstract

Lichen simplex chronicus is a form of chronic localized pruritus with a secondary dermatitis, and one of the most common types of chronic itch conditions, esti-mated to affect more than 10% of the general popu-lation. However, despite its prevalence and burden, there has been limited research into the pathogene-sis and aetiology of lichen simplex chronicus, which, historically, made it a challenging condition to treat. In recent years, our understanding of this condition, along with that of pruritus and the itch-scratch cycle, has increased greatly, enabling a substantial increase in treatment options. In addition, there are several new promising treatments currently in development and trials. This article discusses the definition, epide-miology, clinical characteristics, pathophysiology, and current therapeutic options for lichen simplex chroni-cus, in order to highlight recent advancements in this field.