Mechanism of the Antiobesity Action of Chondroitin Sulfate from Nasal Cartilage of Salmon.

Abstract

Dietary triacylglycerol (TG) is known to be a source of body fat. In this study, we investigated the effects of chondroitin sulfate from the nose cartilage of salmon (salmon CS) on the digestion and absorption of TG, and also the antiobesity effect of salmon CS in mice with obesity induced by a high-fat diet. Salmon CS was found to inhibit the hydrolysis of TG by pancreatic lipase and also the absorption of fatty acids (one of the hydrolysates of TG), in brush border membrane vesicles prepared from rat jejunum. Mice were given free access to high-fat diets containing the salmon CS at levels of 0%, 3%, 7% and 13% for 9 weeks. Body weights were measured at one-week intervals, and parametrial adipose tissue weight, liver weight and lipid concentration, and serum lipid concentration were all measured at the end of feeding. These measured values were significantly lower inthe groups fed on salmon CS at concentrations of 7% and 13% than in the high-fat diet control group. These results suggest that salmon CS suppresses obesity, fatty liver and hyperlipidemia by inhibiting the hydrolysis of TG and the intestinal absorption of fatty acids