GnRH agonist for triggering final oocyte maturation in patients at risk of ovarian hyperstimulation syndrome: Still a controversy?

Abstract

Purpose: An update on the subject of ovarian hyperstimulation syndrome (OHSS) prevention with GnRH agonist ovulation trigger. Methods: Review of pertinent English language studies published during the past 4 years. Results: Randomized prospective studies support the notion that agonist trigger completely eliminates OHSS. Conflicting results regarding on going pregnancy rate probably reflect different approaches to luteal phase support. Embryos obtained and frozen after agonist trigger yield good clinical outcome in subsequent thaw cycles. Conclusions: The notion that agonist trigger can eliminate OHSS is strongly supported by randomized controlled trials. Further research is needed to assess optimal luteal support post agonist trigger. © 2008 Springer Science+Business Media, LLC.