α-nitro ketone synthesis using N-acylbenzotriazoles

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Abstract

Readily available N-acylbenzotriazoles 2a-1 (derived from a variety of aliphatic, (hetero)aromatic, and N-protected α-amino carboxylic acids) smoothly convert primary 3a-c and α-functionalized primary nitroalkanes 3d into the corresponding α-nitro ketones 5a-p in yields of 39-86% (average 63%). © 2005 American Chemical Society.

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Katritzky, A. R., Abdel-Fattah, A. A. A., Gromova, A. V., Witek, R., & Steel, P. J. (2005). α-nitro ketone synthesis using N-acylbenzotriazoles. Journal of Organic Chemistry, 70(23), 9211–9214. https://doi.org/10.1021/jo051231x

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