Synthesis of primary amines by one-pot reductive amination of aldehydes

Abstract

We report here a novel, one-pot, two-step reductive Amination of aldehydes for the atom economical synthesis of primary amine. The Amination step has been carried out with the hydroxyl ammonium chloride and does not require the use of a base. In the subsequent reduction step, a stanous chloride has been used. The operational simplicity, the short reaction times, and the mild reaction conditions add to the value of this method as a practical alternative to the reductive Amination of aldehydes.