Association of IL-10 promoter polymorphism -1082 G/A with adverse outcome in severe sepsis and septic shock

Abstract

Introduction: IL-10 is an anti-inflammatory cytokine with pleiotropic effect in immunoregulation and inflammation. Several recent papers reported association of the IL-10 -1082G allele with adverse outcome in sepsis [1,2]. The study objective was to investigate whether IL-10 promoter polymorphism -1082 G/A is associated with adverse outcome in severe sepsis and septic shock patients. Methods: The study was conducted in the mixed medical-surgical adult ICU of P. Stradins Clinical University Hospital in Riga in 2007 and 2008. A total of 103 critically ill patients who met the proposed severe sepsis and septic shock criteria were included. The IL-10 -1082 polymorphism was genotyped by sequencing. All patients were followed up throughout their stay in the ICU to clinical outcome. The frequency distributions of the genotypes in the subgroups were compared using the Pearson chi-square test. P {