In vitro antilithiatic and antioxidant potential of methanolic extract of polyalthia longifolia leaves

Abstract

Calcium oxalate crystals are responsible for formation of urinary calculi. Traditional therapy based on plants and herbal resources have found beneficial for treatment of kidney stones.  The present study aimed to screen antilithiatic and antioxidant potential of Polyalthia Longifolia leaves methanolic extract. The extract was evaluated for the presence of secondary metabolites, total phenolic content and total flavonoid contents. The high phenolic content in leaves is attributable to the presence of phenol, flavonoid, and tannin which all have antioxidant properties, and same was evaluated and confirmed using nitric oxide assay and lipid peroxidation method. Antilithiatic potential of few secondary metabolites like triterpenoids was confirmed by evaluation calcium oxalate dissolving ability of plant’s methanolic extract. The urinary calculi dissolving ability was of extract was assessed in vitro. The overall findings confirmed the antilithiatic and antioxidant potential of methanolic extract of Polyalthia Longifolia Leaves.