Assessing a sustainable manufacturing route to lapatinib

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Abstract

A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.

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Stark, R. T., Pye, D. R., Chen, W., Newton, O. J., Deadman, B. J., Miller, P. W., … Hii, K. K. (2022). Assessing a sustainable manufacturing route to lapatinib. Reaction Chemistry and Engineering, 7(11), 2420–2426. https://doi.org/10.1039/d2re00267a

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