STUDIES ON METFORMIN HYDROCHLORIDE AND ALPHA-CYCLODEXTRIN INCLUSION COMPLEXES

Abstract

Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type-2 diabetes. Inclusion complexes were prepared between Metformin hydrochloride and alpha- cyclodextrin  in solid and solution state. Inclusion complexes were characterised using UV-VIS, Fluorescence and FTIR Spectroscopic Studies. Phase solubility studies were carried out which determined the 1:1 stoichiometry for the formation of inclusion complexes.