Transdermal Patches: A Complete Review on Transdermal Drug Delivery System

Abstract

Today about 70% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal drug delivery system was emerged. Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy and differs from traditional topical drug delivery. Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs by means of skin. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. This review article covers a brief outline of the principles of transdermal permeation, various components of transdermal patch, approaches of transdermal patch, evaluation of transdermal system, its application with its limitation.