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Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions

Chemical Communications (2015) 51(97) 17217-17220
DOI: 10.1039/c5cc04886a
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Abstract

The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to 22.1 ± 0.5 are reported. Enantioenriched alkynes and triazoles were obtained in ≥80% enantiomeric excess (e.e.).

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APA

Brittain, W. D. G., Buckley, B. R., & Fossey, J. S. (2015). Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions. Chemical Communications, 51(97), 17217–17220. https://doi.org/10.1039/c5cc04886a

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