Role of YY1 in long-range chromosomal interactions regulating Th2 cytokine expression

Abstract

The molecular mechanism for chromatin remodeling and chromosomal interactions at the Th2 cytokine locus is not fully understood. Recently, we showed that transcription factor YY1 is critically involved in these events. This article discusses the possible roles of YY1 in these processes with particular emphasis on long-range chromosomal interactions. © 2014 Landes Bioscience.