MicroRNA-133b expression associates with clinicopathological features and prognosis in glioma

Abstract

Background: Recently, microRNA-133b (miR-133b) dysregulation has been shown to play a key role in several human cancers, as well as glioma. In this study, we aimed to investigate the clinical significance and prognostic value of miR-133b in glioma. Methods: Real-time quantitative PCR was employed to measure the expression level of miR-133b in tissues. Survival analysis was carried out by using the log-rank test and Kaplan–Meier method. Prognostic factors for overall survival were identified by univariate and multivariate analyses using the Cox proportional hazards regression model. Results: The expression level of miR-133b was significantly lower in glioma tissues compared with matched non-cancerous brain tissues (p