Morphological transition triggered by mannose conjugation to a cyclic hexapeptide

Abstract

The present manuscript describes a facile synthesis and the self-assembling behavior of a cyclic hexapeptide functionalized with mannose residues. Cyclic hexapeptides synthesized through cyclodimerization of tripeptides was conjugated to carbohydrate using click reaction. When self-assembling property of this novel conjugate was studied it afforded spherical morphology which was drastically different from self-assembled nanotubes formed by pristine cyclic peptide. Thus, functionalization of mannose to cyclic hexapeptide triggers morphological transition from tubular to spherical structure, opening new avenue for controlled manipulation and modification of peptide based self-assembled structures. ©ARKAT-USA, Inc.