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A janus-faced role of the unfolded protein response in antitumor immunity

OncoImmunology (2013) 2(5)
DOI: 10.4161/onci.23901
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Abstract

The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and antagonizes antitumor T-cell immunity © 2013 Landes Bioscience.

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Mahadevan, N. R., Rodvold, J. J., & Zanetti, M. (2013). A janus-faced role of the unfolded protein response in antitumor immunity. OncoImmunology, 2(5). https://doi.org/10.4161/onci.23901

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