Kinetic of bone turnover markers after osteoporotic vertebral compression fractures in postmenopausal female

Abstract

Background: Osteoporotic fracture occurs mostly at the spine, in which the commonest one is vertebral compression fracture. Bone turnover markers (BTMs) can be applied to assess bone formation and resorption activity. Nevertheless, there are few reports on BTMs changes after osteoporotic vertebral compression fracture. The aim of this study is to investigate the kinetics of bone turnover markers after osteoporotic vertebral compression fractures in postmenopausal female. Methods: Three hundred nine postmenopausal female patients with osteoporotic vertebral compression fractures were included in the study. Fasting blood samples were obtained to analyze the serum concentration of bone turnover markers including osteocalcin (OC), β-isomerized type I collagen amino-terminal peptide (β-CTX), alkaline phosphatase (ALP), type I procollagen amino-terminal peptides (PINP), calcium, and phosphorus. According to periods long after vertebral fracture, all the cases were divided into seven phases: phase 1 (within 3days), phase 2 (3days to 1week), phase 3 (1 to 2weeks), phase 4 (2 to 4weeks), phase 5 (4 to 12weeks), phase 6 (12 to 24weeks), and phase 7 (24weeks to 1year). Comparisons among the phases and kinetics during the phases were conducted. Results: All the kinds of BTM's serum concentration began to increase within 3days after vertebral fracture in phase 1. Osteocalcin and β-CTX had two peaks, the first one in phase 2 (21.4±6.0ng/ml and 0.72±0.17ng/ml, respectively) and the second in phase 6 (25.8±7.5ng/ml and 0.89±0.23ng/ml, respectively). The peak of ALP arrived in phase 4 at the value of 123.9±25.7U/L. PINP reached its peak value (69.50±16.82ng/ml) in phase 6. Serum phosphorus arrived at its first peak (1.21±0.13mmol/L) in phase 2 and the second peak (1.23±0.13mmol/L) in phase 4. Serum calcium reached the first peak (2.30±0.07mmol/L) in phase 3 and the second peak (2.34±0.08mmol/L) in phase 5. Conclusion: The time-dependent variations of BTMs based on the fracture healing process of inflammation, regeneration, and remodeling occur after vertebral fracture. Kinetics of BTMs after vertebral fracture as well as the reference value at each period were established in the present study. It is helpful to assess vertebral fracture healing process according to the kinetics of BTMs.