Design, synthesis and cytotoxicity study of primary amides as histone deacetylase inhibitors

Abstract

Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of the primary amide derivatives adipic monoanilide amide and pimelic monoanilide amide (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.