Differential expression of ANXA2 in eutopic and ectopic endometrium

Abstract

The purpose of this study was to compare the differences in expression of annexin A2 between eutopic and ectopic endometria and to explore the pathogenesis of adenomyosis. In this study, 22 adenomyosis patients who underwent uterine laparotomy in Heilongjiang Provincial Hospital from April 2016 to October 2018 were enrolled as the observation group. The eutopic and ectopic endometria were used for the experiment. In addition, 22 uterine fibroids patients with normal endometrium who underwent open hysterectomy were selected as the control group. The levels of annexin A2 in endometrial tissue and serum were compared between the two groups. The results showed that the annexin A2 level in normal endometrial tissue was significantly lower than that in the eutopic and ectopic endometrial tissue and the annexin A2 level in the ectopic endometrium was significantly higher than that in the eutopic endometrium (p<0.05). The annexin A2 level in the serum of the observation group was significantly (p<0.05) higher than that of the control group. Clinical monitoring of changes in annexin A2 level could be useful as auxiliary diagnostic marker to start treatment of adenomyosis, so as to project prognostic changes more accurately. However, the results of this study still need to be verified with multi-center samples.