Genetics of Down's syndrome and Alzheimer's disease

Abstract

Comments on the article by C. Holms (see record 2002-10593-014) which concluded that in Alzheimer's disease genetic variation influences a number of aspects of clinical phenotype. The author state that the article failed to mention Down's syndrome as being a particular risk factor for the development of early-onset Alzheimer's disease because of triplication of the amyloid precurser gene. (PsycINFO Database Record (c) 2012 APA, all rights reserved)