The correlation between esophageal and abdominal pressures in mechanically ventilated patients undergoing laparoscopic surgery

Abstract

BACKGROUND: Intrathoracic pressure in patients undergoing laparoscopic surgery may be affected by intra-abdominal pressure during surgery. We investigated the relationship between intraabdominal pressure (Pabd) and esophageal pressure (Pes) in mechanically ventilated patients undergoing laparoscopic surgery. METHODS: We prospectively studied 43 consenting patients over 18 y of age who were scheduled for elective laparoscopic surgery with plans for intra-operative intubation and paralysis. After establishing a good level of inter-observer agreement on Pes measurements, Pes was measured by one observer for each patient using an esophageal catheter. Pabd and Pes were recorded before and after abdominal insufflation. We used regression analysis to model the relationship between Pabd and Pes. RESULTS: Patients' ages varied from 22 to 78 y, with a mean of 53.2 = 14.6 y. Body mass index (BMI) varied from 13.7 to 60.5 kg/m2, with a mean of 33.7 = 10.5. PEEP was 5-7 cm H2O for 19 patients and 0 cm H2O for the remainder. Most patients underwent gastric bypass surgery (n = 11); others underwent hernia repair (n = 9), colon resection (n = 7), cholecystectomy (n = 6), and various other surgeries (n = 10). Using univariate analyses, baseline Pabd was significantly correlated with baseline Pes (estimate of model coefficient [95% CI]: 0.79 [0.36 -1.21], R2 = 0.24, P =.001), as was BMI (0.29 [0.19-0.40], R2 = 0.41, P