Allergy to walnuts and hazelnuts in atopic dermatitis patients and analysis of sensitization to molecular components

Abstract

Aim: To evaluate the occurrence of food allergy to walnuts and hazelnuts in atopic dermatitis patients. Methods: The examination of specific IgE to molecular components with Multiplex ISAC testing was performed. The diagnosis of food allergy was confirmed in patients suffering from food reactions to walnuts/hazelnuts together with positive results of specific IgE to molecular components. Results and conclusion: : Altogether 100 atopic dermatitis patients were examined–48 men, 52 women, the average age 40.9 years. Hazelnuts allergy was confirmed in 25% of patients; these patients are majorly allergic to PR 10 protein, minorly to storage proteins. Walnut allergy was confirmed in 14% of patients; these patients are majorly allergic to storage proteins and to non-specific lipid transfer proteins. Sensitization to Bet v 1 homologues and profilins was associated with mild symptoms; nsLTPs and seed storage proteins were related to severe reactions.