The plasma membrane receptor natural killer group 2 member D (NKG2D) underpins a major mechanism whereby natural killer (NK) and T cells recognize malignant cells. We have recently demonstrated that the epithelial-to-mesenchymal transition, one of the first steps of metastatic dissemination, is under the control of an immunological checkpoint that relies on NKG2D-mediated immune responses. © 2013 Landes Bioscience.
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López-Soto, A., Zapico, L. H., Acebes-Huerta, A., Rodrigo, L., & Gonzalez, S. (2013). Regulation of NKG2D signaling during the epithelial-to-mesenchymal transition. OncoImmunology, 2(9). https://doi.org/10.4161/onci.25820