Evaluation of dissolution media containing a novel synthetic surfactant by in vitro testing of BCS class II drugs

Abstract

The objective of this study was to employ a tailor-made, surface-active agent (phosphonobile acid) in the design of dissolution media that more closely reflect various luminal fluid physicochemical parameters such as buffer capacity, osmolarity, surface tension, and pH. The proposed media are simple to prepare and use, and thus can be explored for routine application. Three BCS II drugs, glimepiride, dipyridamole, and ibuprofen, were selected for the study. In vitro dissolution profiles obtained with the proposed media were compared with profiles obtained in FaSSIF and FeSSIF media using the f2 similarity factor. Dissolution in the proposed media correlate well with the dissolution obtained in FaSSIF and FeSSIF media.