IruO is a reductase for heme degradation by IsdI and IsdG proteins in staphylococcus aureus

Abstract

Background: Staphylococcus aureus utilizes heme as an iron source during an infection. Results: An oxidoreductase, IruO, can supply electrons to IsdI and IsdG for heme degradation and iron extraction. Conclusion: IruO is likely the in vivo reductant for heme degradation to the staphylobilins. Significance: Heme degradation is a potential target for anti-S. aureus therapeutics. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.