Preparation and characterization of PLGA-based biocompatible nanoparticles for sustained delivery of growth factor for wound healing applications

Abstract

Platelet-derived growth factor-BB (PDGF-BB) loaded PLGA: poloxamer blend nanoparticles (PLGF) were studied for their physical, chemical and biological characteristics using in vitro and in vivo experimental models. The particle size of PLGF was between 100 and 150 nm with 85% encapsulation efficiency. In vitro released kinetics revealed a slow and sustained release of growth factor (GF) for a month. Furthermore, biological studies confirmed the non-toxic, and non-irritant nature of nanoparticles and angiogenesis stimulating ability of GF released from nanoparticles demonstrating their potential for the treatment of chronic wounds in future.