Serum AMH level can predict the risk of cycle cancellation and the chances of good ovarian response, independently of patient's age or FSH

Abstract

Objective: In the recent years, anti-Müllerian hormone (AMH) has been shown to represent a reliable marker of the ovarian reserve. In this study, we evaluate the risk of cycle cancellation and the chances of good ovarian response to controlled hyperstimulation and of pregnancy according to serum AMH measured prior to assisted reproduction procedures in females undergoing intracytoplasmic sperm injection. Method: An analytic observational study included females undergoing ICSI between in a single center. Subgroup analyses were performed by grouping patients according to FSH levels or to their age. Results: The risk of cycle cancellation decreased from 64% in patients with serum AMH ≤3 pmol/L (0.42 ng/ mL) to 21% with AMH ≥15 pmol/L (2.10 ng/mL). The rate of good response increased from almost null in patients with AMH ≤3 pmol/L to 61% in those with AMH ≥15 pmol/L. Pregnancy rate increased moderately, but significantly, from 31% with AMH ≤3 pmol/L to 35% with AMH ≥15 pmol/L. Conclusion: Here we provide estimates of those outcomes according to the values of serum AMH, in general and in subgroups according to patient's age or serum FSH, which are helpful for the clinician and the couple in their decision making about starting an ART treatment. © Todos os direitos reservados a SBRA - Sociedade Brasileira de Reprodução Assistida.