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The Novel CTX-M-116 β-Lactamase Gene Discovered in Proteus mirabilis Is Composed of Parts of the CTX-M-22 and CTX-M-23 Genes

Antimicrobial Agents and Chemotherapy (2013) 57(3) 1552-1555
DOI: 10.1128/AAC.01471-12
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Abstract

The novel β-lactamase gene blaCTX-M-116 was identified in a Proteus mirabilis nosocomial isolate recovered from the urine of a patient in Moscow in 2005. DNA sequence analysis showed blaCTX-M-116 to be a hybrid gene consisting of 5= blaCTX-M-23 (nucleotides 1 to 278) and 3= blaCTX-M-22 (nucleotides 286 to 876) moieties separated by an intervening putative site of recombination (GTTAAAT). A retrospective analysis of available blaCTX-M genes in the GenBank database revealed 19 blaCTX-M genes that display the same hybrid structure. Copyright © 2013, American Society for Microbiology.

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Fursova, N., Pryamchuk, S., Kruglov, A., Abaev, I., Pecherskikh, E., Kartsev, N., … Dyatlov, I. (2013). The Novel CTX-M-116 β-Lactamase Gene Discovered in Proteus mirabilis Is Composed of Parts of the CTX-M-22 and CTX-M-23 Genes. Antimicrobial Agents and Chemotherapy, 57(3), 1552–1555. https://doi.org/10.1128/AAC.01471-12

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