Monocyclic β-Lactam Antibiotics: Synthesis And Antibacterial Activity Of 4-(Substituted Ethyl)-2-Azetidinone-1-Sulfonic Acid Derivatives

Abstract

The synthesis and antibacterial activity of sodium (3S,4R)-3-[2-(2-aminothiazol-4-yl)-(Z)-2-(O-substituted oxyimino)acetamido]-2-azetidinone-1-sulfonates having various substituted ethyl groups at the C-4 position are described. Among various substituents explored, the (substituted isothiuronio)ethyl groups were found to have strong antibacterial activity against a variety of Gram-negative bacteria, and moreover, the ethylene isothiuronium derivative exhibited moderate antibacterial activity against Staphylococcus aureus. © 1987, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.