Dietary Folic Acid and the Activity of Brain Cholinergic and γ-Aminobutyric Acid (GABA) Enzymes

Abstract

Charles River CD male rats were randomly divided into 3 groups of five each and placed on folate deficient, folate excess, and control diets respectively. Glutamate decarboxylase GA D y-aminohutyrate aminotransferase (GABA-T), choline acetyltransferase (ChAc), and acetylcholinesterase (AChE) were assayed in the rat brains after 6 weeks of dietary treatment. Neither folate deficiency nor folate supplementation influenced the enzymes associated with GABA and acetylcholine metabolism. © 1980, Canadian Neurological Sciences Federation. All rights reserved.