In-vivo biological effect of Carica papaya leaf extracts on P-407 induced hyperlipidemic Wistar rats

Abstract

To determine the biological effect of Carica papaya leaf extracts on Poloxamer induced hyperlipidemia. Thirty-five healthy albino rats of the same sexes weighing 150-200g were divided into seven; group given feed and water only, group induced by an intra-peritoneal injection of P-407, groups induced and treated with methanol, ethanol, ethyl acetate, n-butanol and n-hexane leaf extracts. In all the groups, P-407 and the extracts were administered at a dose of 1000mg/kg and 30mg/kg body weight respectively. At the end of the 14 day, the animals were sacrificed and blood sample were collected for determination of serum levels of: Total cholesterol (TC), Triacylglycerides (TG), Low-density lipoprotein (LDL) and High-density lipoprotein (HDL). The studies showed that animals in induced treated groups significantly (P<0.05) lower serum levels of TC, TG, LDL and significantly (P<0.05) increased HDL when compared to the P-407 induced hyperlipidemia control. The studies show the phytotherapeutic effect of Carica papaya leaf extracts (methanol, ethanol, ethyl acetate, n-butanol and n-hexane) in P-407 induced hyperlipidemia.