ISOLATED SYSTOLIC HYPERTENSION IN SAUDI PATIENTS WITH DIABETIC NEPHROPATHY: A SERIOUS HEALTH CONCERN: PP.30.192

Abstract

Background: Isolated systolic hypertension (ISH) is serious health concern causes its threat to the occurrence of stroke, kidney disease and dementia. It is 3 times more prevalence in patients with Diabetes Mellitus Urgent intensified treatment is needed to prevent disability and improve the life quality. Objective: To see the prevalence and outcome of ISH in Saudi patients with diabetic nephropathy (DN). Method: Single centre retrospective study conducted between January 1989 and January 2004 on 503 D N patients with proteinuria in a tertiary hospital in Riyadh, Saudi Arabia. Definitions of hypertension were according to the seventh report of the Joint National Committee of the Prevention, Detection, Evaluation and Treatment of high blood pressure (JNC 7). Results: 503 proteinuric DN patients, 269 (53.5%) males age 64.5-12.3 yrs. prevalence of hypertension was 409 (81.3%). At baseline 136 patients were controlled and 273 patients were uncontrolled. In those 273 patients, ISH was observed in 97 (35.5%) patients, isolated diastolic hypertension (IDH) was present in 14(5.1%) patients and both systolic and diastolic hypertension (SDH) was present in 162 (59.3%) patients. Patients with ISH were elderly with mean age of 65.7+ 11 yrs, Obese with BMI 29.6+5. Females were at a significantly higher risk, duration of diabetes 15.3+7.3yrs patients with ISH were having higher incidence of stroke, Myocardial infarction, background retinopathy, cataract, and demise than the other subtypes as shown in the table below. (Table presented). Conclusion: Isolated systolic hypertension is quite frequent. Females are at significantly higher risk Because of comparatively higher incidence of complications ISH is a serious health concern. Aggressive treatment and close monitoring is warranted in DN patients to improve the outcome and quality of life.